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CD106 (VCAM-1) Monoclonal Antibody (429), Functional Grade, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

£131.00 - £247.00

Specifications

Antigen CD106 (VCAM-1)
Clone 429
Concentration 1 mg/mL
Applications Flow Cytometry, Functional Assay, Neutralization
Classification Monoclonal
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15258537
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Affymetrix eBioscience
16-1061-82
100 μg
£131.00
100µg
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Estimated Shipment: 07-05-2024
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15268537
View Documents Promotion Details
Affymetrix eBioscience
16-1061-85
500 μg
£247.00
500µg
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Estimated Shipment: 15-04-2024
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Description

Description

Description: The 429 monoclonal antibody reacts with mouse CD106 (Vascular Cell Adhesion Molecule-1, VCAM-1), a 110 kDa transmembrane glycoprotein expressed by myeloid lineage and bone marrow stromal cells. Endothelial cells constitutively express low levels of CD106 and upregulate it upon cytokine stimulation. CD106 binds to integrin alpha4beta1 (VLA-4, CD49d/CD29) and Integrin a4b7 (LPAM-1) and these interactions in the bone marrow and thymus are important for early lymphocyte and myeloid development. Cytokine-mediated upregulation of CD106 on endothelial cells suggests a role for this antigen in the inflammatory response. Applications Reported: The 429 antibody has been reported for use in flow cytometric analysis. It has also been reported in blocking of CD106 in functional studies. Applications Tested: The 429 antibody has been tested by flow cytometric analysis of mouse bone marrow cells. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Endotoxin: Less than 0.001 ng/ug antibody as determined by the LAL assay. Storage and handling: Use in a sterile environment. Filtration: 0.2 μm post-manufacturing filtered.

VCAM-1 is a cell surface sialoglycoprotein expressed by cytokine activated endothelium. The protein has a number of functions including the regulation of leukocyte migration, leukocyte-endothelial cell adhesion and signal transduction and may play a role in a number of inflammatory diseases.
Specifications

Specifications

CD106 (VCAM-1)
1 mg/mL
Monoclonal
Liquid
RUO
PBS with no preservative; pH 7.2
adhesion molecule VCAM-1; CD106; CD106 antigen; DKFZp779G2333; INCAM100; INCAM-100; MGC99561; sCD106; soluble CD106; soluble VCAM 1; sVCAM 1; vascular cell adhesion molecule; vascular cell adhesion molecule 1; vascular cell adhesion molecule-1; vascular cell adhesion protein 1; V-CAM 1; Vcam1; Vcam-1; VCAM1B
VCAM1
Primary
4° C
VCAM1
429
Flow Cytometry, Functional Assay, Neutralization
Functional Grade
Rat
Mouse
P29533
22329
IgG2a κ
Affinity chromatography
Antibody
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