CD106 (VCAM-1) Rat anti-Mouse, Clone: 429, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-1061-81

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15248537

Quantity Price
1 £ 48.31 / 50µg
Estimated Shipment date
from Supplier 03-04-2017
Add to basket


Description and Specification

Specification

Conjugate Unlabeled
Gene Alias VCAM1, vascular cell adhesion molecule-1
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Concentration 1mg/mL
Isotype IgG2a
Applications Flow Cytometry
Applications Functional Assay
Quantity 50μg
Antigen CD106 (VCAM-1)
Species Reactivity Mouse
Regulatory Status RUO
Clone 429
Format Purified
Storage Requirements Store at 2-8°C.
Formulation aqueous buffer, no sodium azide
Host Species Rat

The 429 monoclonal antibody reacts with mouse CD106 (Vascular Cell Adhesion Molecule-1, VCAM-1), a 110kDa transmembrane glycoprotein expressed by myeloid lineage and bone marrow stromal cells. Endothelial cells constitutively express low levels of CD106 and upregulate it upon cytokine stimulation. CD106 binds to integrin α4β1 (VLA-4, CD49d/CD29) and Integrin a4b7 (LPAM-1) and these interactions in the bone marrow and thymus are important for early lymphocyte and myeloid development. Cytokine-mediated upregulation of CD106 on endothelial cells suggests a role for this antigen in the inflammatory response.