CD106 (VCAM-1) Rat anti-Mouse, Clone: 429, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-1061-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15268537

Quantity Price
1 £ 182.82 / 500µg
EU Stock 4
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Description and Specification

Specification

Species Reactivity Mouse
Conjugate Unlabeled
Concentration 1mg/mL
Monoclonal or Polyclonal Monoclonal
Quantity 500μg
Applications Flow Cytometry
Applications Functional Assay
Storage Requirements Store at 2-8°C.
Formulation aqueous buffer, no sodium azide
Host Species Rat
Antigen CD106 (VCAM-1)
Regulatory Status RUO
Primary or Secondary Primary
Format Purified
Gene Alias VCAM1, vascular cell adhesion molecule-1
Isotype IgG2a
Clone 429

The 429 monoclonal antibody reacts with mouse CD106 (Vascular Cell Adhesion Molecule-1, VCAM-1), a 110kDa transmembrane glycoprotein expressed by myeloid lineage and bone marrow stromal cells. Endothelial cells constitutively express low levels of CD106 and upregulate it upon cytokine stimulation. CD106 binds to integrin α4β1 (VLA-4, CD49d/CD29) and Integrin a4b7 (LPAM-1) and these interactions in the bone marrow and thymus are important for early lymphocyte and myeloid development. Cytokine-mediated upregulation of CD106 on endothelial cells suggests a role for this antigen in the inflammatory response.