CD106 (VCAM-1) Rat anti-Mouse, Clone: 429, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-1061-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15258537

Quantity Price
1 £ 97.22 / 100µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Format Purified
Antigen CD106 (VCAM-1)
Primary or Secondary Primary
Concentration 1mg/mL
Applications Flow Cytometry
Applications Functional Assay
Monoclonal or Polyclonal Monoclonal
Quantity 100μg
Regulatory Status RUO
Formulation aqueous buffer, no sodium azide
Clone 429
Conjugate Unlabeled
Gene Alias VCAM1, vascular cell adhesion molecule-1
Storage Requirements Store at 2-8°C.
Isotype IgG2a
Species Reactivity Mouse
Host Species Rat

The 429 monoclonal antibody reacts with mouse CD106 (Vascular Cell Adhesion Molecule-1, VCAM-1), a 110kDa transmembrane glycoprotein expressed by myeloid lineage and bone marrow stromal cells. Endothelial cells constitutively express low levels of CD106 and upregulate it upon cytokine stimulation. CD106 binds to integrin α4β1 (VLA-4, CD49d/CD29) and Integrin a4b7 (LPAM-1) and these interactions in the bone marrow and thymus are important for early lymphocyte and myeloid development. Cytokine-mediated upregulation of CD106 on endothelial cells suggests a role for this antigen in the inflammatory response.