CD106 (VCAM-1) Rat anti-Mouse, Clone: 429, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-1061-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15287157

Quantity Price
1 £ 133.91 / 500µg
Estimated Shipment date
from Supplier 02-05-2017
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Description and Specification

Specification

Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Regulatory Status RUO
Concentration 0.5mg/mL
Monoclonal or Polyclonal Monoclonal
Gene Alias VCAM1, vascular cell adhesion molecule-1
Format Purified
Storage Requirements Store at 2-8°C.
Isotype IgG2a
Clone 429
Applications Flow Cytometry
Applications Functional Assay
Applications Immunohistochemistry (Frozen)
Applications Immunoprecipitation
Species Reactivity Mouse
Host Species Rat
Antigen CD106 (VCAM-1)
Quantity 500μg
Conjugate Unlabeled
Primary or Secondary Primary

The 429 monoclonal antibody reacts with mouse CD106 (Vascular Cell Adhesion Molecule-1, VCAM-1), a 110kDa transmembrane glycoprotein expressed by myeloid lineage and bone marrow stromal cells. Endothelial cells constitutively express low levels of CD106 and upregulate it upon cytokine stimulation. CD106 binds to integrin α4β1 (VLA-4, CD49d/CD29) and Integrin a4b7 (LPAM-1) and these interactions in the bone marrow and thymus are important for early lymphocyte and myeloid development. Cytokine-mediated upregulation of CD106 on endothelial cells suggests a role for this antigen in the inflammatory response.