CD106 (VCAM-1) Rat anti-Mouse, Biotin, Clone: 429, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 13-1061-81

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15229679

Quantity Price
1 £ 48.31 / 50µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Primary or Secondary Primary
Format Conjugated
Quantity 50μg
Monoclonal or Polyclonal Monoclonal
Conjugate Biotin
Gene Alias VCAM1, vascular cell adhesion molecule-1
Concentration 0.5mg/mL
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Host Species Rat
Antigen CD106 (VCAM-1)
Storage Requirements Store at 2-8°C. Do not freeze.
Clone 429
Applications Flow Cytometry
Isotype IgG2a
Regulatory Status RUO
Species Reactivity Mouse

The 429 monoclonal antibody reacts with mouse CD106 (Vascular Cell Adhesion Molecule-1, VCAM-1), a 110kDa transmembrane glycoprotein expressed by myeloid lineage and bone marrow stromal cells. Endothelial cells constitutively express low levels of CD106 and upregulate it upon cytokine stimulation. CD106 binds to integrin α4β1 (VLA-4, CD49d/CD29) and Integrin a4b7 (LPAM-1) and these interactions in the bone marrow and thymus are important for early lymphocyte and myeloid development. Cytokine-mediated upregulation of CD106 on endothelial cells suggests a role for this antigen in the inflammatory response.