CD106 (VCAM-1) Mouse anti-Rat, Clone: eBioMR106 (MR106), eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-1060-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15247157

Quantity Price
1 £ 91.11 / 100µg
Estimated Shipment date
from Supplier 02-05-2017
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Description and Specification

Specification

Conjugate Unlabeled
Isotype IgG1
Applications Flow Cytometry
Applications Immunohistochemistry (Frozen)
Applications Immunoprecipitation
Applications Western Blotting
Primary or Secondary Primary
Species Reactivity Rat
Concentration 0.5mg/mL
Storage Requirements Store at 2-8°C.
Monoclonal or Polyclonal Monoclonal
Host Species Mouse
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Clone eBioMR106 (MR106)
Gene Alias VCAM1, vascular cell adhesion molecule-1
Regulatory Status RUO
Antigen CD106 (VCAM-1)
Format Purified
Quantity 100μg

The eBioMR106 monoclonal antibody reacts with rat CD106 (Vascular Cell Adhesion Molecule-1, VCAM-1), a 110kDa transmembrane glycoprotein expressed by myeloid lineage and bone marrow stromal cells. Endothelial cells constitutively express low levels of CD106 and further upregulate VCAM-1 upon cytokine stimulation. CD106 binds to integrin α4β1 (VLA-4, CD49d/CD29) and Integrin α4β7 (LPAM-1) and these interactions in the bone marrow and thymus are important for early lymphocyte and myeloid development. Cytokine-mediated upregulation of CD106 on endothelial cells suggests a role for this antigen in the inflammatory response.