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CD101 Mouse anti-Human, Clone: BB27, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-1019-80

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15237137

  • £60.53 / 25µg


Estimated Shipment
30-11-2017
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Disclaimers:

For Research Use Only.


Description

Description

The monoclonal antibody BB27 reacts to human CD101 also known as V7 antigen, a member of the Ig superfamily. CD101 is a disulfide linked homodimer of unknown function. Expression of CD101 is found on monocytes, granulocytes and dendritic cells (Langerhan-like cells HLA-DR, CD1a, CD1c). In addition expression on T lymphocytes is important for cell activation. CD101+ CD28+ cells are very responsive to CD28 signaling. In combination with anti-CD28 or suboptimal levels of anti-CD3, anti-CD101 can increase proliferation thereby suggesting an activating role. The monoclonal antibody BB27 has been shown to inhibit the T cell reactivity in allogeneic and antigen-specific mixed DC-T cell cultures. Recently it has been demonstrated that mouse CD101 is found on a subpopulation of regulatory T cells (CD4, CD25, Foxp3 positive) that have high suppressor activity. Expression of CD101 on human PBMCs shows staining of about 30% of the Foxp3 positive cells. Studies have not confirmed higher suppressor activity in the human CD101 population.
Specifications

Specifications

CD101
BB27
Unlabeled
Purified
Murine
25μg
Store at 2-8°C.
Monoclonal
Immunoprecipitation
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
V7 antigen, IGSF 2, IGSF-2
IgG1
RUO
Primary
Human