CD10 Mouse anti-Human, PE-Cy5, Clone: eBioCB-CALLA (CB-CALLA), eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 15-0106-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15587706

Quantity Price
1 £ 72.77 / 25 tests
EU Stock 2
Add to basket


Description and Specification

Specification

Host Species Mouse
Regulatory Status RUO
Species Reactivity Human
Monoclonal or Polyclonal Monoclonal
Isotype IgG2b
Conjugate PE-Cy5
Primary or Secondary Primary
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Clone eBioCB-CALLA (CB-CALLA)
Quantity 25 tests
Antigen CD10
Format Conjugated
Applications Flow Cytometry
Gene Alias Common Acute Lymphocytic Leukemia antigen (CALLA), Neprilysin
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.125μg)/test

The eBioCB-CALLA monoclonal antibody recognizes human CD10 (CALLA, NEP, enkephalinase, Neprilysin), which is a 100 kDa, type II cell surface glycoprotein originally identified for its expression on most acute lymphoblastic leukemias (ALL). Subsequently, CD10 was shown to be the same molecule as the neutral endopeptidase (NEP), or KII-NA. CD10 is a Zn2+-dependent metallo-peptidase with endothelin, glucagon, gastrin, neurotensin and bradykinin included among its substrates. CD10 is involved in the regulation of chemotactic and inflammatory processes involving neutrophils. In B cells, CD10 regulates stromal cell-dependent B lymphopoiesis and expression has also been reported on mature B cells in germinal centres. In addition to the hematopoietic compartment, other major sites of CD10 expression are the brush border of enterocytes and renal tubules and glomeruli. There is partial blocking of the eBioCB-CALLA and MEM-78 monoclonal antibodies indicating that they recognize similar epitopes.