CD10 Mouse anti-Human, Alexa Fluor 700, Clone: CB-CALLA, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 56-0106-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15520337

Quantity Price
1 £ 78.88 / 25 tests
Estimated Shipment date
from Supplier 04-05-2017
Add to basket


Description and Specification

Specification

Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Host Species Mouse
Primary or Secondary Primary
Isotype IgG2b
Quantity 25 tests
Gene Alias Common Acute Lymphocytic Leukemia antigen (CALLA), Neprilysin
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal or Polyclonal Monoclonal
Clone eBioCB-CALLA (CB-CALLA)
Species Reactivity Human
Format Conjugated
Concentration 5μL (0.25μg)/test
Applications Flow Cytometry
Regulatory Status RUO
Conjugate Alexa Fluor 700
Antigen CD10

The eBioCB-CALLA monoclonal antibody recognizes human CD10 (CALLA, NEP, enkephalinase, Neprilysin), which is a 100 kDa, type II cell surface glycoprotein originally identified for its expression on most acute lymphoblastic leukemias (ALL). Subsequently, CD10 was shown to be the same molecule as the neutral endopeptidase (NEP), or KII-NA. CD10 is a Zn2+-dependent metallo-peptidase with endothelin, glucagon, gastrin, neurotensin and bradykinin included among its substrates. CD10 is involved in the regulation of chemotactic and inflammatory processes involving neutrophils. In B cells, CD10 regulates stromal cell-dependent B lymphopoiesis and expression has also been reported on mature B cells in germinal centres. In addition to the hematopoietic compartment, other major sites of CD10 expression are the brush border of enterocytes and renal tubules and glomeruli. There is partial blocking of the eBioCB-CALLA and MEM-78 monoclonal antibodies indicating that they recognize similar epitopes.