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CCL8 (MCP-2) Mouse anti-Human, eFluor 660, Clone: DWZEE, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 50-9789-41

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15580137

  • £66.65 / 25 tests


Estimated Shipment date
from Supplier 28-07-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

This DWZEE monoclonal antibody reacts with human CCL8. CCL8, also known as MCP-2 (Monocyte Chemotactic Protein 2), is a member of the CC- subfamily of chemokines and is most closely related to CCL2 (MCP-1) and CCL7 (MCP-3). They are secreted by a variety of cell types in response to inflammatory stimuli and play critical roles in the recruitment of leukocytes to areas of inflammation. While all three MCP proteins are potent chemoattractants of monocytes and T cells, CCL7 appears to have the broadest range of activity, as it has also been demonstrated to attract activated NK cells, eosinophils, basophils, and neutrophils. CCL8 has also been demonstrated to attract NK cells, eosinophils, and basophils, but requires higher concentrations to do so. CCL8 signals via the g protein-coupled receptor CCR5, which is shared with other CC-chemokines. CCR5 is the primary co-receptor for HIV entry, which the virus binds through the gp120 envelope protein. All CCR5 ligands demonstrate potent inhibition of virus entry into the cell, both through steric hindrance of gp120-CCR5 interaction, and ligand-mediated receptor internalization.
Description & Specifications

Specifications

CCL8 (MCP-2)
DWZEE
eFluor 660
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry (Intracellular Staining)
5μL (0.125μg)/test
Conjugated
CC Chemokine 8, Monocyte Chemotactic Protein 2, MCP-2
IgG1
RUO
Primary
Human