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CCL4 (MIP-1 beta) Mouse anti-Human, PerCP-eFluor 710, Clone: FL34Z3L, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 46-7540-41

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15579366

  • £75.30 / 25 tests


Estimated Shipment date
from Supplier 21-09-2017
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Disclaimers:

For Research Use Only.


Description

Description

This FL34Z3L monoclonal antibody reacts with human CCL4. CCL4, also known as MIP-1 beta (Macrophage Inflammatory Protein 1 beta), is a member of the CC- subfamily of chemokines and is most closely related to CCL3, or MIP-1 alpha. These proteins play critical roles in the recruitment of leukocytes to the site of inflammation. While both CCL3 and CCL4 are chemoattractant for monocytes, macrophages, and dendritic cells, CCL4 preferentially attracts CD4+ T cells, while CD8+ T cells are more responsive to CCL3. In addition to its chemotactic functions, CCL4 induces the release of proinflammatory cytokine, mast cells degranulation, and NK cell activation.

CCL4 signaling is mediated by the G protein-coupled receptors CCR1, CCR4, and CCR5, which are shared with CCL3 and CCL5 (RANTES). CCR5 is the primary co-receptor for HIV entry, which the virus binds through the gp120 envelope protein. All CCR5 ligands demonstrate potent inhibition of virus entry into the cell, both through steric hindrance of gp120-CCR5 interaction, and ligand-mediated receptor internalization.
Specifications

Specifications

CCL4 (MIP-1 beta)
FL34Z3L
PerCP-eFluor 710
Conjugated
Murine
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry (Intracellular Staining)
5μL (0.03μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
C-C Motif Chemokine 4, Macrophage Inflammatory Protein 1 beta
IgG2a
RUO
Primary
Human