CCL3 (MIP-1 alpha) Rat anti-Mouse, PerCP-eFluor 710, Clone: DNT3CC, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 46-7532-82

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15569366

Quantity Price
1 £ 195.53 / 100µg
Estimated Shipment date
from Supplier 03-04-2017
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Description and Specification

Specification

Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Species Reactivity Mouse
Concentration 0.2mg/mL
Isotype IgG2a
Conjugate PerCP-eFluor 710
Antigen CCL3 (MIP-1 alpha)
Clone DNT3CC
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Gene Alias C-C Motif Chemokine 3, Macrophage Inflammatory Protein 1-alpha
Regulatory Status RUO
Format Conjugated
Host Species Rat
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Applications Flow Cytometry (Intracellular Staining)
Quantity 100μg

This DNT3CC monoclonal antibody reacts with mouse CCL3. CCL3, also known as MIP-1 alpha (Macrophage Inflammatory Protein 1 alpha), is a member of the CC- subfamily of chemokines and is most closely related to CCL4, or MIP-1 beta. These proteins play critical roles in the recruitment of leukocytes to the site of inflammation. While both CCL3 and CCL4 will attract monocytes, macrophages, and dendritic cells, CCL3 preferentially attracts CD8+ T cells, while CD4+ T cells are more responsive to CCL4. In addition to its chemotactic functions, CCL3 induces inflammatory cytokine secretion, mast cell degranulation, and NK cell activation. It has also been reported to inhibit hematopoetic stem cell proliferation and may be responsible for the maintenance of these cells in a quiescent state. CCL3 signaling is mediated by the G protein-coupled receptors CCR1, CCR4, and CCR5, which are shared with CCL4 and CCL5 (RANTES).