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CCL3 (MIP-1 alpha) Rat anti-Mouse, eFluor 660, Clone: DNT3CC, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 50-7532-82

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15550047

  • £176.70 / 100µg


Estimated Shipment date
from Supplier 31-07-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

This DNT3CC monoclonal antibody reacts with mouse CCL3. CCL3, also known as MIP-1 alpha (Macrophage Inflammatory Protein 1 alpha), is a member of the CC- subfamily of chemokines and is most closely related to CCL4, or MIP-1 beta. These proteins play critical roles in the recruitment of leukocytes to the site of inflammation. While both CCL3 and CCL4 will attract monocytes, macrophages, and dendritic cells, CCL3 preferentially attracts CD8+ T cells, while CD4+ T cells are more responsive to CCL4. In addition to its chemotactic functions, CCL3 induces inflammatory cytokine secretion, mast cell degranulation, and NK cell activation. It has also been reported to inhibit hematopoetic stem cell proliferation and may be responsible for the maintenance of these cells in a quiescent state. CCL3 signaling is mediated by the G protein-coupled receptors CCR1, CCR4, and CCR5, which are shared with CCL4 and CCL5 (RANTES).
Description & Specifications

Specifications

CCL3 (MIP-1 alpha)
DNT3CC
eFluor 660
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Rat
100μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry (Intracellular Staining)
0.2mg/mL
Conjugated
C-C Motif Chemokine 3, Macrophage Inflammatory Protein 1-alpha
IgG2a
RUO
Primary
Murine