c-Met (HGF Receptor) Rat anti-Mouse, FITC, Clone: eBioclone 7, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 11-8854-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15288369

Quantity Price
1 £ 66.65 / 25µg
Estimated Shipment date
from Supplier 03-04-2017
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Description and Specification

Specification

Host Species Rat
Gene Alias hepatocyte growth factor receptor
Isotype IgG1
Concentration 0.5mg/mL
Quantity 25μg
Conjugate FITC
Regulatory Status RUO
Monoclonal or Polyclonal Monoclonal
Format Conjugated
Species Reactivity Mouse
Clone eBioclone 7
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Antigen c-Met (HGF Receptor)
Applications Flow Cytometry
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary

The eBioclone 7 monoclonal antibody was generated against a mouse c-Met-Ig fusion protein, and reacts with mouse c-Met-transfected cells. Mouse c-Met (HGFR) is a 170kDa receptor tyrosine kinase (RTK) expressed by epithelial cells of the brain, kidney, liver and other tissues. Binding of its ligand, Hepatocyte Growth Factor (HGF), triggers receptor autophosphorylation, and activation of several downstream effectors including the mitogen-activated protein kinases ERK-1 and ERK-2, and PLC gamma. Activation of the c-Met signal transduction pathway leads to mulitple cellular responses including cell motility, scattering, proliferation, survival and angiogenesis. Mutations in human c-Met have been implicated in the development of several malignancies.