c-Met (HGF Receptor) Rat anti-Mouse, FITC, Clone: eBioclone 7, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 11-8854-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15298369

Quantity Price
1 £ 170.59 / 100µg
EU Stock 4
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Description and Specification

Specification

Concentration 0.5mg/mL
Isotype IgG1
Species Reactivity Mouse
Clone eBioclone 7
Monoclonal or Polyclonal Monoclonal
Quantity 100μg
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Conjugate FITC
Format Conjugated
Applications Flow Cytometry
Antigen c-Met (HGF Receptor)
Gene Alias hepatocyte growth factor receptor
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Host Species Rat
Regulatory Status RUO
Primary or Secondary Primary

The eBioclone 7 monoclonal antibody was generated against a mouse c-Met-Ig fusion protein, and reacts with mouse c-Met-transfected cells. Mouse c-Met (HGFR) is a 170kDa receptor tyrosine kinase (RTK) expressed by epithelial cells of the brain, kidney, liver and other tissues. Binding of its ligand, Hepatocyte Growth Factor (HGF), triggers receptor autophosphorylation, and activation of several downstream effectors including the mitogen-activated protein kinases ERK-1 and ERK-2, and PLC gamma. Activation of the c-Met signal transduction pathway leads to mulitple cellular responses including cell motility, scattering, proliferation, survival and angiogenesis. Mutations in human c-Met have been implicated in the development of several malignancies.