c-Met (HGF Receptor) Rat anti-Human, FITC, Clone: eBioclone 97, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 11-8858-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15546606

Quantity Price
1 £ 72.77 / 25 tests
EU Stock 4
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Description and Specification

Specification

Quantity 25 Tests
Format Conjugated
Conjugate FITC
Gene Alias HGFR, hepatocyte growth factor receptor
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Clone eBioclone 97
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Monoclonal or Polyclonal Monoclonal
Antigen c-Met (HGF Receptor)
Isotype IgG1
Species Reactivity Human
Host Species Rat
Regulatory Status RUO
Concentration 5μL (1.0μg)/test
Primary or Secondary Primary
Applications Flow Cytometry

The eBioclone 97 monoclonal antibody was generated against a human c-Met-Ig fusion protein, and reacts with human c-Met (HGFR)-transfected cells. Human c-Met is a 145kDa receptor tyrosine kinase (RTK) expressed by epithelial cells of the brain, kidney, liver and other tissues. Binding of its ligand, Hepatocyte Growth Factor (HGF), triggers receptor autophosphorylation, and activation of several downstream effectors including the mitogen-activated protein kinases ERK-1 and ERK-2, and PLC gamma;. Activation of the c-Met signal transduction pathway leads to mulitple cellular responses including cell motility, scattering, proliferation, survival and angiogenesis. Mutations in human c-Met have been implicated in the development of several malignancies.