c-Met (HGF Receptor) Rat anti-Human, Clone: eBioclone 97, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-8858-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15228107

Quantity Price
1 £ 54.42 / 25µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Species Reactivity Human
Conjugate Unlabeled
Formulation aqueous buffer, 0.09% sodium azide, contains carrier protein/stabilizer if necessary
Storage Requirements Store at 2-8°C.
Concentration 0.5mg/mL
Quantity 25μg
Monoclonal or Polyclonal Monoclonal
Gene Alias hepatocyte growth factor receptor
Primary or Secondary Primary
Clone eBioclone 97
Antigen c-Met (HGF Receptor)
Format Purified
Isotype IgG1
Regulatory Status RUO
Host Species Rat
Applications Flow Cytometry

97 monoclonal antibody was generated against a human c-Met-Ig fusion protein, and reacts with human c-Met (HGFR)-transfected cells. Human c-Met is a 145kDa receptor tyrosine kinase (RTK) expressed by epithelial cells of the brain, kidney, liver and other tissues. Binding of its ligand, Hepatocyte Growth Factor (HGF), triggers receptor autophosphorylation, and activation of several downstream effectors including the mitogen-activated protein kinases ERK-1 and ERK-2, and PLC gamma;. Activation of the c-Met signal transduction pathway leads to mulitple cellular responses including cell motility, scattering, proliferation, survival and angiogenesis. Mutations in human c-Met have been implicated in the development of several malignancies.