c-ErbB3/HER3 Mouse anti-Human, PerCP-eFluor 710, Clone: SGP1, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 46-6555-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15549336

Quantity Price
1 £ 87.96 / 25 tests
Estimated Shipment date
from Supplier 03-04-2017
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Description and Specification

Specification

Primary or Secondary Primary
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Conjugate PerCP-eFluor 710
Applications Flow Cytometry
Species Reactivity Human
Monoclonal or Polyclonal Monoclonal
Antigen c-ErbB3/HER3
Quantity 25 tests
Host Species Mouse
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Regulatory Status RUO
Format Conjugated
Clone SGP1
Concentration 5μL (0.125μg)/test
Isotype IgG1

This SGP1 monoclonal antibody reacts with human c-ErbB3, which is also known as HER3. This epidermal growth factor (EGF) receptor family member is expressed on normal human tissues, particularly on neurons and cells of the gastrointestinal tract. c-ErbB3 is overexpressed in a variety of cancers, including breast, ovary, and gastrointestinal carcinomas. Upon binding its ligand heregulin beta-1, c-ErbB3 is activated by heterodimerization with ErbB2 or EGFR1. Dependent on PI3K signaling, c-ErbB3 mediates tumor cell invasion, intravasation, and metastasis. Expression of this cell surface receptor has been used as a prognostic marker for breast cancer.

The SGP1 antibody has been reported to stimulate anchorage-independent growth of breast cancer cell lines.