c-ErbB3/HER3 Mouse anti-Human, PerCP-eFluor 710, Clone: SGP1, eBioscience™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 46-6555-41
Code : NEW
Additional Details : Weight : 0.23750kg
DescriptionThis SGP1 monoclonal antibody reacts with human c-ErbB3, which is also known as HER3. This epidermal growth factor (EGF) receptor family member is expressed on normal human tissues, particularly on neurons and cells of the gastrointestinal tract. c-ErbB3 is overexpressed in a variety of cancers, including breast, ovary, and gastrointestinal carcinomas. Upon binding its ligand heregulin beta-1, c-ErbB3 is activated by heterodimerization with ErbB2 or EGFR1. Dependent on PI3K signaling, c-ErbB3 mediates tumor cell invasion, intravasation, and metastasis. Expression of this cell surface receptor has been used as a prognostic marker for breast cancer.
The SGP1 antibody has been reported to stimulate anchorage-independent growth of breast cancer cell lines.
|aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|
|Store at 2-8°C. Do not freeze. Light-sensitive material.|