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c-ErbB3/HER3 Mouse anti-Human, PerCP-eFluor 710, Clone: SGP1, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 46-6555-42

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15559336

  • £195.53 / 100 tests


Estimated Shipment date
from Supplier 21-11-2017
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Disclaimers:

For Research Use Only.


Description

Description

This SGP1 monoclonal antibody reacts with human c-ErbB3, which is also known as HER3. This epidermal growth factor (EGF) receptor family member is expressed on normal human tissues, particularly on neurons and cells of the gastrointestinal tract. c-ErbB3 is overexpressed in a variety of cancers, including breast, ovary, and gastrointestinal carcinomas. Upon binding its ligand heregulin beta-1, c-ErbB3 is activated by heterodimerization with ErbB2 or EGFR1. Dependent on PI3K signaling, c-ErbB3 mediates tumor cell invasion, intravasation, and metastasis. Expression of this cell surface receptor has been used as a prognostic marker for breast cancer.

The SGP1 antibody has been reported to stimulate anchorage-independent growth of breast cancer cell lines.
Specifications

Specifications

c-ErbB3/HER3
SGP1
PerCP-eFluor™ 710
Conjugated
IgG1
RUO
Primary
Human
Flow Cytometry
5μL (0.125μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
100 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal