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Brachyury Mouse anti-Human, Clone: X1AO2, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9770-82

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15557666

  • £136.24 / 100µg


Estimated Shipment date
from Supplier 29-08-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

The monoclonal antibody X1AO2 recognizes human Brachyury, a 47kDa protein encoded by the T gene and functioning as a nuclear transcription factor. This transcription factor binds to specific DNA regions near the palindromic sequence TCACACCT (T-site) through a region in its N-terminus, called the T-box. Brachyury functions during embryogenesis to regulate midline development by establishing the anterior/posterior axis through the regulation of genes involved in mesoderm formation and differentiation. Brachyury is the primary mesoderm marker used to distinguish differentiation of embryonic stem cells into a mesenchymal stem cell lineage. Variations in the T gene in humans are associated with neural tube defects and chordomas. Expression of brachyury is also increased in advanced stage lung tumors and tumor cell lines.
Description & Specifications

Specifications

Brachyury
X1AO2
Unlabeled
Purified
IgG2b
RUO
Primary
Human
Western Blot
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
100μg
Store at 2-8°C.
Monoclonal