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Brachyury Mouse anti-Human, Clone: X1AO2, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9770-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15547666

  • £55.59 / 25µg


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For Research Use Only.


Description

Description

The monoclonal antibody X1AO2 recognizes human Brachyury, a 47kDa protein encoded by the T gene and functioning as a nuclear transcription factor. This transcription factor binds to specific DNA regions near the palindromic sequence TCACACCT (T-site) through a region in its N-terminus, called the T-box. Brachyury functions during embryogenesis to regulate midline development by establishing the anterior/posterior axis through the regulation of genes involved in mesoderm formation and differentiation. Brachyury is the primary mesoderm marker used to distinguish differentiation of embryonic stem cells into a mesenchymal stem cell lineage. Variations in the T gene in humans are associated with neural tube defects and chordomas. Expression of brachyury is also increased in advanced stage lung tumors and tumor cell lines.
Specifications

Specifications

Brachyury
X1AO2
Unconjugated
Purified
IgG2b
RUO
Primary
Human
Western Blot
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
25μg
Store at 2-8°C.
Monoclonal
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