Brachyury Mouse anti-Human, Clone: X1AO2, eBioscience™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 14-9770-80
Code : NEW
Additional Details : Weight : 0.09500kg
DescriptionThe monoclonal antibody X1AO2 recognizes human Brachyury, a 47kDa protein encoded by the T gene and functioning as a nuclear transcription factor. This transcription factor binds to specific DNA regions near the palindromic sequence TCACACCT (T-site) through a region in its N-terminus, called the T-box. Brachyury functions during embryogenesis to regulate midline development by establishing the anterior/posterior axis through the regulation of genes involved in mesoderm formation and differentiation. Brachyury is the primary mesoderm marker used to distinguish differentiation of embryonic stem cells into a mesenchymal stem cell lineage. Variations in the T gene in humans are associated with neural tube defects and chordomas. Expression of brachyury is also increased in advanced stage lung tumors and tumor cell lines.
|aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|
|Store at 2-8°C.|