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BMI-1 Mouse anti-Human, Clone: AF27, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9702-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15517616

This item has been discontinued and is no longer available. View the product for possible alternatives or contact our Product Support team on 01509 555888 for assistance

Disclaimers:

For Research Use Only.


Specifications

Description

The monoclonal antibody AF27 recognizes human BMI-1 (B cell-specific Moloney murine leukemia virus integration site 1), a member of the polycomb group (PcG) proteins responsible for repression of gene expression through recognition and modification of histone methylation and chromatin structure. BMI-1 contains a ring finger domain, a helix-turn-helix domain necessary for inducing telomerase activity and is a member of the polycomb repressive complex 1 (PRC1). BMI-1 localizes to the nucleus and plays an important role in self-renewal of normal as well as hematopoietic, embryonic, neural, and other stem cell populations through regulation of genes involved in proliferation such as Sox2 and KLF4. Decreased BMI-1 expression is associated with differentiation, while overexpression is frequently found in variety of cancers. BMI-1 has been shown to be essential for epithelial to mesenchymal transition (EMT) in head and neck and breast cancers and elevated BMI-1 expression correlates with poor prognosis in patients with neuroblastoma, glioma, non-Hodgkin B-cell lymphoma, oropharyngeal squamous cell cancer, non-small cell lung cancer, and primary and metastatic melanoma.
Description & Specifications

Specifications

BMI-1
AF27
Unlabeled
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
IgG2a
RUO
Primary
Human
Microscopy
0.5mg/mL
Purified
Murine
25μg
Store at 2-8°C.
Monoclonal