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Blimp1 Rat anti-Mouse, PE, Clone: 5E7, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 12-9850-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15587236

  • £91.11 / 25µg


EU Stock 3
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Disclaimers:

For Research Use Only.


Description

Description

This 5E7 monoclonal antibody recognizes mouse B lymphocyte-induced maturation protein-1 (Blimp-1), which is also known as Prdm1. Blimp-1 is a transcriptional repressor with five zinc finger domains. Blimp-1 is expressed by terminally differentiating B and T cells. Blimp-1 is also expressed by some dendritic cells, and some NK cells. This transcriptional repressor is required for B cell differentiation into plasma cells and serves as a critical antagonist of CD4+ follicular helper T cell differentiation. While Blimp-1 is not required for priming and development of T and B cell effector function, it is critical for effector cell terminal differentiation. Blimp-1 promotes effector molecule secretion while suppressing proliferation. Blimp-1 also acts as a transcriptional antagonist of Bcl-6 and inhibits genes that are related to memory cell differentiation.
Specifications

Specifications

Blimp1
5.00E+07
PE
Conjugated
Rat
25μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry (Intracellular Staining)
0.2mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Prdm1, B lymphocyte induced maturation protein 1
IgG2a
RUO
Primary
Murine
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