Blimp1 Rat anti-Mouse, Clone: 6D3, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-5963-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15227637

Quantity Price
1 £ 152.25 / 100µg
EU Stock 1
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Description and Specification

Specification

Monoclonal or Polyclonal Monoclonal
Isotype IgG2a
Storage Requirements Store at 2-8°C.
Format Purified
Concentration 0.5mg/mL
Clone 6D3
Host Species Rat
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Western Blotting
Antigen Blimp1
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Conjugate Unlabeled
Quantity 100μg
Species Reactivity Mouse
Gene Alias Blimp-1, PRDM1, PRDIBF1
Regulatory Status RUO
Primary or Secondary Primary

This 6D3 monoclonal antibody reacts with B lymphocyte-induced maturation protein-1 (Blimp-1), a transcriptional repressor expressed in B and T cells. This approximately 90kDa protein contains five consecutive Kruppel-like zinc finger domains by which it binds DNA. In B cells, Blimp-1 promotes terminal differentiation into antibody-secreting plasma cells during a primary immune response. In addition, Blimp-1 has been implicated in germinal center formation in response to T-dependent and T-independent antigens, as well as in some diffuse large B cell lymphomas. Expressed in CD4+ and CD8+ effector/memory T cells and FoxP3+ regulatory T cells, reports have suggested possible roles for Blimp-1 in T cell homeostasis and suppression of IL-2 production. Moreover, by suppressing Th1 differentiation, Blimp-1 plays a role in T helper cell differentiation. Finally, Blimp-1 has been demonstrated to play a significant role in the terminal differentiation of effector and effector memory CD8+ T cells during viral infection.