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BIX 01294, Tocris Bioscience™

GLP and G9a inhibitor

Brand:  Tocris (Bio-Techne) 336410

Code : Z1

Additional Details : Weight : 0.01100kg

Quantity 10mg

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Product Code. 13442894

  • £195.51 / 10mg

Estimated Shipment date
from Supplier 21-11-2019

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Description

Description

GLP and G9a histone lysine methyltransferase inhibitor (IC50 values are 0.7 and 1.7 μM respectively) that displays no activity at other histone methyltransferases up to 37 μM. Modulates H3K9me2 levels in mammalian cells and potentiates induction of pluripotent stem cells from somatic cells in vitro. Also inhibits H3K36 methylation by oncoproteins NSD1, NSD2 and NSD3 (IC50 values are 40 - 112 μM).
Specifications

Chemical Identifiers

1392399-03-9
600.026
bix01294 hydrochloride, bix 01294 trihydrochloride, bix-01294 trihydrochloride, 2-hexahydro-4-methyl-1h-1,4-diazepin-1-yl-6,7-dimethoxy-n-1-phenylmethyl-4-piperidinyl-4-quinazolinamine trihydrochloride, bix 01294 trihydrochloride hydrate, n-1-benzylpiperidin-4-yl-6,7-dimethoxy-2-4-methyl-1,4-diazepan-1-yl quinazolin-4-amine trihydrochloride, bix01294 trihydrochloride
N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine;trihydrochloride
C28H41Cl3N6O2
FMURUEPQXKJIPS-UHFFFAOYSA-N
46945860
CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)CC5=CC=CC=C5)OC)OC.Cl.Cl.Cl

Specifications

10mg
1392399-03-9
bix01294 hydrochloride, bix 01294 trihydrochloride, bix-01294 trihydrochloride, 2-hexahydro-4-methyl-1h-1,4-diazepin-1-yl-6,7-dimethoxy-n-1-phenylmethyl-4-piperidinyl-4-quinazolinamine trihydrochloride, bix 01294 trihydrochloride hydrate, n-1-benzylpiperidin-4-yl-6,7-dimethoxy-2-4-methyl-1,4-diazepan-1-yl quinazolin-4-amine trihydrochloride, bix01294 trihydrochloride
CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)CC5=CC=CC=C5)OC)OC.Cl.Cl.Cl
600.026
600.02
BIX 01294
C28H41Cl3N6O2
FMURUEPQXKJIPS-UHFFFAOYSA-N
N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine;trihydrochloride
46945860
>98%
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