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BIBU 1361 dihydrochloride, Tocris Bioscience™

Selective inhibitor of EGFR-kinase

Brand:  Tocris (Bio-Techne) 241710

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 10mg

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Product Code. 13441174

  • £182.28 / 10mg

Estimated Shipment date
from Supplier 25-11-2019

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Description

Description

Potent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM). Displays ∽ 100-fold lower potency against ErbB2 (IC50 = 290 nM) and is selective over a range of other related tyrosine kinases (IC50 > 10 μM). Blocks downstream EGFR signaling events such as MAPKK/MAPK activation. Oral administration inhibits growth of established human xenografts in athymic mice.
Specifications

Chemical Identifiers

793726-84-8
516.871
bibu 1361 dihydrochloride, n-3-chloro-4-fluorophenyl-6-4-diethylamino methyl piperidin-1-yl pyrimido 5,4-d pyrimidin-4-amine dihydrochloride, n-3-chloro-4-fluorophenyl-6-4-diethylamino methyl-1-piperidinyl-pyrimido 5,4-d pyrimidin-4-amine dihydrochloride, n-3-chloro-4-fluorophenyl-6-4-diethylamino methyl piperidin-1-yl pyrimido 5,4-d 1,3 diazin-4-amine dihydrochloride, n-3-chloro-4-fluorophenyl-6-4-diethylamino methyl piperidin-1-yl pyrimido 5,4-d pyrimidin-4-amine-hydrogen chloride 1/2, pyrimido 5,4-d pyrimidin-4-amine,n-3-chloro-4-fluorophenyl-6-4-diethylamino methyl-1-piperidinyl
N-(3-chloro-4-fluorophenyl)-6-[4-(diethylaminomethyl)piperidin-1-yl]pyrimido[5,4-d]pyrimidin-4-amine;dihydrochloride
C22H29Cl3FN7
ZNNWCQCQUKAMGL-UHFFFAOYSA-N
46861539
CCN(CC)CC1CCN(CC1)C2=NC=C3C(=N2)C(=NC=N3)NC4=CC(=C(C=C4)F)Cl.Cl.Cl

Specifications

10mg
793726-84-8
bibu 1361 dihydrochloride, n-3-chloro-4-fluorophenyl-6-4-diethylamino methyl piperidin-1-yl pyrimido 5,4-d pyrimidin-4-amine dihydrochloride, n-3-chloro-4-fluorophenyl-6-4-diethylamino methyl-1-piperidinyl-pyrimido 5,4-d pyrimidin-4-amine dihydrochloride, n-3-chloro-4-fluorophenyl-6-4-diethylamino methyl piperidin-1-yl pyrimido 5,4-d 1,3 diazin-4-amine dihydrochloride, n-3-chloro-4-fluorophenyl-6-4-diethylamino methyl piperidin-1-yl pyrimido 5,4-d pyrimidin-4-amine-hydrogen chloride 1/2, pyrimido 5,4-d pyrimidin-4-amine,n-3-chloro-4-fluorophenyl-6-4-diethylamino methyl-1-piperidinyl
CCN(CC)CC1CCN(CC1)C2=NC=C3C(=N2)C(=NC=N3)NC4=CC(=C(C=C4)F)Cl.Cl.Cl
516.871
516.87
BIBU 1361 dihydrochloride
C22H29Cl3FN7
ZNNWCQCQUKAMGL-UHFFFAOYSA-N
N-(3-chloro-4-fluorophenyl)-6-[4-(diethylaminomethyl)piperidin-1-yl]pyrimido[5,4-d]pyrimidin-4-amine;dihydrochloride
46861539
>97%
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