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  5. Tocris Bioscience™ BI 4394

Tocris Bioscience™ BI 4394

Product Code. 30279875
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Product Code. 30279875 Supplier Tocris Bioscience™ Supplier No. 8842/10

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Description

Highly potent and selective MMP-13 inhibitor

BI 4394 is a highly potent and selective MMP-13 inhibitor (IC50 = 1 nM). BI 4394 inhibits the degradation of isolated bovine nasal cartilage explants (IC50 = 31 nM). It shows high selectivity (>1000 fold) for MMP-13 over other MMPs. In vivo, BI 4394 decreases the mean arthritic score vs control in a murine model of rheumatoid arthritis, when administered at a dose of 100 mg/kg over a 14-day period. BI 4394 is orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 2-Ethyl 5-[3-[[[(4-carboxyphenyl)methyl]amino]carbonyl]-1-methyl-1H-pyrazol-5-yl]-1H-indole-2-carboxylate
CAS 1222173-37-6
Quantity 10 mg
Target Synthetic Metalloprotease Inhibitors
Molecular Formula C24H22N4O5
Purity 0.98
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