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beta Catenin Mouse anti-Human, Mouse, eFluor® 660, Clone: 15B8, eBioscience™
Mouse Monoclonal Antibody
£78.50 - £169.00
Specifications
Antigen | beta Catenin |
---|---|
Clone | 15B8 |
Target Species | Human, Mouse |
Conjugate | eFluor™ 660 |
Isotype | IgG1, kappa |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15579916
|
Affymetrix eBioscience
50-2567-41 |
25 Tests |
£78.50
25 tests |
Estimated Shipment 23-02-2021 |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
15589916
|
Affymetrix eBioscience
50-2567-42 |
100 Tests |
£169.00
100 tests |
Estimated Shipment 23-02-2021 |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
Description
A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. eFluor® 660 is a replacement for Alexa Fluor® 647. eFluor® 660 emits at 659 nm and is excited with the red laser (633 nm). Please make sure that your instrument is capable of detecting this fluorochome. Excitation: 633-647 nm; Emission: 668 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered. Beta-catenin, an adherens junction (AJ) protein, was originally identified as a component of cell-cell adhesion structures. AJs are necessary for the creation and maintece of epithelial cell layers by regulating cell growth and adhesion between cells. Beta-catenin interacts with the cytoplasmic domain of E-cadherin and links E-cadherin to alpha-catenin, which in turn mediates anchorage of the E-cadherin complex to the cortical actin cytoskeleton. Studies show that Beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases, phosphatases and Wnt/Wingless. The interplay between beta-catenin, cytoskeletal complexes and signaling pathways may regulate morphogenesis. Beta-catenin is expressed in several hair follicle cell types, basal and peripheral matrix cells, and cells of the outer and inner root sheats. A pathological role of beta-catenin has been identified in pilomatrixoma (PTR), medulloblastoma (MDB), colorectal cancer (CRC), ovarian cancer, and tumor development. In the nucleus, beta-catenin serves to co activate a family of Lef/Tcf transcription factors that stimulate transcription of target genes including those encoding cyclin D and c-myc that promote cell proliferation. The influence on cell proliferation is the molecular basis for the role of beta-catenin in tumorgenesis, specifically, solid tumors of the breast, colon, liver, lung, gastric, prostate, and skin.Specifications
beta Catenin | |
Human, Mouse | |
IgG1, kappa | |
Monoclonal | |
Liquid | |
Antibody | |
4° C, store in dark, DO NOT FREEZE! |
15B8 | |
eFluor™ 660 | |
Flow Cytometry | |
Primary | |
Monoclonal | |
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2 | |
RUO |
For Research Use Only.