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Bcl-6 Rat anti-Mouse, PE, Clone: BCL-DWN, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 12-5453-82

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15587006

  • £213.39 / 100µg


EU Stock 6
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Disclaimers:

For Research Use Only.


Specifications

Description

This BCL-DWN monoclonal antibody reacts with mouse Bcl-6, which is also known as B-cell lymphoma 6. A member of the POZ family of transcriptional repressors, Bcl-6 is expressed most abundantly in germinal center B cells, as well as in differentiating and activated B cells. This 79kDa protein is essential for germinal center B cell proliferation and survival. Moreover, during B cell development, Bcl-6 plays an important role in promoting pre-B cell survival to enable the generation of a diverse B cell repertoire. Moreover, Bcl-6 is expressed constitutively in diffuse large B cell lymphomas (DLBCLs), Burkitt’s lymphoma, and non-Hodgkin’s lymphoma. Reports also suggest expression of Bcl-6 in CD4+ T follicular helper cells and memory T cells. Bcl-6 has been reported to be antagonized by Blimp-1.
Description & Specifications

Specifications

Bcl-6
BCL-DWN
PE
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
IgG2a
RUO
Primary
Murine
Flow Cytometry (Intracellular Staining)
0.2mg/mL
Conjugated
Rat
100μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal