Bcl-6 Mouse anti-Human, PerCP-eFluor 710, Clone: BCL-UP, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 46-9880-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15589456

Quantity Price
1 £ 94.28 / 25 tests
Estimated Shipment date
from Supplier 04-04-2017
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Description and Specification

Specification

Isotype IgG1
Clone BCL-UP
Regulatory Status RUO
Primary or Secondary Primary
Concentration 5μL (0.03μg)/test
Host Species Mouse
Species Reactivity Human
Applications Flow Cytometry (Intracellular Staining)
Monoclonal or Polyclonal Monoclonal
Quantity 25 tests
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Conjugate PerCP-eFluor 710
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Format Conjugated
Antigen Bcl-6
Gene Alias B-cell lymphoma 6

The monoclonal antibody BCL-UP recognizes Bcl-6, also known as B-cell lymphoma 6,which is a member of the POZ family of transcriptional repressors. Bcl-6 is expressed most abundantly in germinal center B cells, as well as in differentiating and activated B cells. This 79kDa protein is essential for germinal center B cell proliferation and survival. During B cell development, Bcl-6 plays an important role in promoting pre-B cell survival to enable the generation of a diverse B cell repertoire. Moreover, Bcl-6 is expressed constitutively in diffuse large B cell lymphomas (DLBCLs), Burkitt’s lymphoma, and non-Hodgkin’s lymphoma. Reports also suggest expression of Bcl-6 in CD4+ T follicular helper cells and memory T cells. Bcl-6 has been reported to be antagonized by Blimp-1.