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Bcl-6 Mouse anti-Human, PerCP-eFluor 710, Clone: BCL-UP, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 46-9880-41

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15589456

  • £94.28 / 25 tests


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For Research Use Only.


Description

Description

The monoclonal antibody BCL-UP recognizes Bcl-6, also known as B-cell lymphoma 6,which is a member of the POZ family of transcriptional repressors. Bcl-6 is expressed most abundantly in germinal center B cells, as well as in differentiating and activated B cells. This 79kDa protein is essential for germinal center B cell proliferation and survival. During B cell development, Bcl-6 plays an important role in promoting pre-B cell survival to enable the generation of a diverse B cell repertoire. Moreover, Bcl-6 is expressed constitutively in diffuse large B cell lymphomas (DLBCLs), Burkitt’s lymphoma, and non-Hodgkin’s lymphoma. Reports also suggest expression of Bcl-6 in CD4+ T follicular helper cells and memory T cells. Bcl-6 has been reported to be antagonized by Blimp-1.
Specifications

Specifications

Bcl-6
BCL-UP
PerCP-eFluor™ 710
Conjugated
Murine
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry (Intracellular Staining)
5μL (0.03μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
B-cell lymphoma 6
IgG1
RUO
Primary
Human
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