Bcl-6 Mouse anti-Human, Mouse, Clone: GI191E, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9887-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15258207

Quantity Price
1 £ 152.25 / 100µg
EU Stock 1
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Description and Specification

Specification

Host Species Murine
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Western Blot
Regulatory Status RUO
Format Purified
Isotype IgG1
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Storage Requirements Store at 2-8°C.
Clone GI191E
Gene Alias B-cell lymphoma 6, Bcl6
Quantity 100μg
Species Reactivity Human, Mouse
Antigen Bcl-6
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL
Conjugate Unlabeled

This GI191E monoclonal antibody reacts with mouse and human Bcl-6, which is also known as B-cell lymphoma 6. A member of the POZ family of transcriptional repressors, Bcl-6 is expressed most abundantly in germinal center B cells, as well as in differentiating and activated B cells. This 79kDa protein is essential for germinal center B cell proliferation and survival. Moreover, during B cell development, Bcl-6 plays an important role in promoting pre-B cell survival to enable the generation of a diverse B cell repertoire. Moreover, Bcl-6 is expressed constitutively in diffuse large B cell lymphomas (DLBCLs), Burkitt’s lymphoma, and non-Hodgkin’s lymphoma. Reports also suggest expression of Bcl-6 in CD4+ T follicular helper cells and memory T cells. Bcl-6 has been reported to be antagonized by Blimp-1.