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Bcl-2 Mouse anti-Mouse, Rat, PE-Cyanine7, Clone: 10C4, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 25-6992-42

Code : NEW

Additional Details : Weight : 0.23750kg

 View more versions of this product

Product Code. 15568616

  • £165.00 / 100 tests

In stock, ready to ship: 2

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Description

Description

Please protect this vial and stained samples from light. Fixation: Samples can be stored in IC Fixation Buffer (cat. 00-8222) (100 µL of cell sample + 100 µL of IC Fixation Buffer) or 1-step Fix/Lyse Solution (cat. 00-5333) for up to 3 days in the dark at 4°C with minimal impact on brightness and FRET efficiency/compensation. Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically. Excitation: 488-561 nm; Emission: 775 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 μm post-manufacturing filtered. BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. The BCL-2 family members are also characterized by dimerizing to further modulate apoptosis. Bag1, for example, has been found to form a heterodimer with BCL-2 resulting in the enhancement of the anti-apoptotic effect of BCL-2. Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis. Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. Two transcript variants of BCL-2, produced by alternate splicing, differ in their C-terminal ends. The overexpression of BCL-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.
Specifications

Specifications

Bcl-2
Monoclonal
5 μL/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
P49950, P10417
AW986256, Bcl-2, C430015F12Rik, D630044D05Rik, D830018M01Rik
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse, Rat
Flow Cytometry
10C4
PE-Cyanine7
Bcl2
Liquid
Bcl2
IgG1, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
12043, 24224
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For Research Use Only.