Bcl-2 Mouse anti-Mouse, Rat, Clone: 10C4, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-6992-81

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15227967

Quantity Price
1 £ 66.65 / 50µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Gene Alias B cell lymphoma 2
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Antigen Bcl-2
Concentration 0.5mg/mL
Isotype IgG1
Monoclonal or Polyclonal Monoclonal
Species Reactivity Mouse, Rat
Regulatory Status RUO
Conjugate Unlabeled
Applications Flow Cytometry (Intracellular Staining)
Applications Immunoprecipitation
Applications Western Blotting
Primary or Secondary Primary
Host Species Mouse
Storage Requirements Store at 2-8°C.
Quantity 50μg
Format Purified
Clone 10C4

The 10C4 monoclonal antibody reacts with mouse and rat Bcl-2, also known as B cell lymphoma 2. Bcl-2 is the founding member of the Bcl-2 family of evolutionarily-conserved proteins that regulate cell death/survival. Members of the Bcl-2 family include the pro-apoptotic proteins BAD, Bax, and Bim, and the anti-apoptotic proteins Bcl-2, Bcl-xL, and Mcl-1. Bcl-2 inhibits apoptosis by preventing the release of cytochrome c from the mitochondria. Mutation of Bcl-2 or overexpression of Bcl-2 due to chromosomal translocation has been identified as a contributing factor in numerous cancers. In developing thymocytes, Bcl-2 is expressed at high levels in CD4-CD8- double negative and in CD4+ and CD8+ single positive thymocytes; Bcl-2 expression is greatly diminished in CD4+CD8+ double positive thymocytes.