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Cytokeratin Pan Type II, clone: AE3, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9000-80

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15228117

  • £80.90 / 25µg


Estimated Shipment
30-07-2018
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Description

Description

Description: The monoclonal antibody AE3 recognizes many members of the basic (Type II) cytokeratin family. Cytokeratins are intermediate filament proteins comprising one component of the cytoskeleton. There are two large families of cytokeratins, acidic and basic, but all contain the same basic domains (i.e. an alpha-helical core with an N- and C-terminal domain). The proteins are expressed in epithelial cells, but are developmentally regulated. Many tumors also express these cytokeratins, and their expression can help identify the origin of a neoplasm. The AE3 monoclonal antibody recognizes the 65 to 67 triplet, 64, 59, 58, 56, 54 and 52kD proteins (also known as cytokeratin 1, 2, 3, 4, 5, 6, 7 and 8) in mouse, human, rat, primate (cynomolgus and rhesus), dog, cat, rabbit and chicken.Applications Reported: This AE3 antibody has been reported for use in western blotting, immunohistochemical staining of frozen tissue sections, immunohistochemical staining of formalin-fixed paraffin embedded tissue sections, immunohistochemical staining, and immunocytochemistry.Applications Tested: This AE3 antibody has been by tested western blot on SDS-reduced lysates from MCF7 cells at less than or equal to 2 μg/mL. It is recommended that the antibody be titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

Basic Cytokeratin
Monoclonal
0.5mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q6EIY9, Q6EIZ1, P02538, P04264, P05787, P08729, P12035, P13647, P19013, P35908, P04104, P07744, P11679, P50446, Q3TTY5, Q922U2, Q9DCV7, Q29426
keratin
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
CanineþChickenþHumanþMurineþNon-human PrimateþRabbitþRhesus
ImmunocytochemistryþImmunohistochemistryþImmunohistochemistryþImmunohistochemistry (Frozen)þWestern Blot
AE3
Unconjugated
KRT6A
Purified
KRT1, KRT2, KRT3, KRT4, KRT5, Krt6a, KRT7, KRT8
IgG1
25μg
Store at 2-8°C.
Primary
3848, 3849, 3850, 3851, 3852, 3853, 3855, 3856
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For Research Use Only.