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Azilsartan, Tocris Bioscience™

Potent AT1 receptor inverse agonist; antihypertensive

Brand:  RD Systems (Bio-Techne) 4553/10

Code : Z1

Additional Details : Weight : 0.00010kg

Quantity 10mg

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Product Code. 13444924

  • £135.00 / 10mg

Estimated Shipment
28-06-2019

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Description

Description

Potent angiotensin II type 1 (AT1) receptor inverse agonist (IC50 = 2.6 nM at the human AT1 receptor). Inhibits angiotensin II-induced IP1 accumulation in COS-7 cells; decreases maximal contraction of rabbit aortic strips in a concentration-dependent manner (pD'2 = 9.9). Antihypertensive; prevents vascular cell proliferation and expression of PAI-1.
Specifications

Chemical Identifiers

147403-03-0
456.458
azilsartan, unii-f9nux55p23, azilsartan tak-536, chembl57242, 2-ethoxy-1-2'-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl biphenyl-4-yl methyl-1h-benzimidazole-7-carboxylic acid, 1h-benzimidazole-7-carboxylic acid, 1-2'-2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl 1,1'-biphenyl-4-yl methyl-2-ethoxy, 1-2'-2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl 1,1'-biphenyl-4-yl methyl-2-ethoxy-1h-benzimidazole-7-carboxylic acid, 2-ethoxy-1-2'-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl biphenyl-4-yl methyl-1h-benzo d imidazole-7-carboxylic acid, 2-ethoxy-1-2'-4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl biphenyl-4-yl methyl benzimidazole-7-carboxylic acid, 2-ethoxy-3-4-2-5-oxo-2h-1,2,4-oxadiazol-3-yl phenyl phenyl methyl benzimidazole-4-carboxylic acid
CHEBI:68850
CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NC(=O)ON5)C(=O)O
C25H20N4O5
KGSXMPPBFPAXLY-UHFFFAOYSA-N
9825285
2-ethoxy-3-[[4-[2-(5-oxo-2H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid

Specifications

Azilsartan
147403-03-0
azilsartan, unii-f9nux55p23, azilsartan tak-536, chembl57242, 2-ethoxy-1-2'-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl biphenyl-4-yl methyl-1h-benzimidazole-7-carboxylic acid, 1h-benzimidazole-7-carboxylic acid, 1-2'-2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl 1,1'-biphenyl-4-yl methyl-2-ethoxy, 1-2'-2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl 1,1'-biphenyl-4-yl methyl-2-ethoxy-1h-benzimidazole-7-carboxylic acid, 2-ethoxy-1-2'-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl biphenyl-4-yl methyl-1h-benzo d imidazole-7-carboxylic acid, 2-ethoxy-1-2'-4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl biphenyl-4-yl methyl benzimidazole-7-carboxylic acid, 2-ethoxy-3-4-2-5-oxo-2h-1,2,4-oxadiazol-3-yl phenyl phenyl methyl benzimidazole-4-carboxylic acid
CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NC(=O)ON5)C(=O)O
456.458
CHEBI:68850
>98%
10mg
C25H20N4O5
KGSXMPPBFPAXLY-UHFFFAOYSA-N
2-ethoxy-3-[[4-[2-(5-oxo-2H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid
9825285
456.45
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