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Axitinib, Tocris Bioscience™

Potent VEGFR-1, -2 and -3 inhibitor

Brand:  RD Systems (Bio-Techne) 4350/50

Code : Z1

Additional Details : Weight : 0.00050kg

Quantity 50mg

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Product Code. 13464604

  • £813.00 / 50mg


Estimated Shipment
28-06-2018
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Description

Description

Potent inhibitor of VEGFR-2, -3, and -1 (IC50 values are 0.2, 0.1-0.3, and 1.2 nM respectively). Exhibits minimal activity against a panel of ∽100 protein kinase. Inhibits angiogenesis and vascular permeability. Also a high affinity BCR-ABL1 (T315I) inhibitor (Ki = 149 pM for autophosphorylated ABL1 (T315I)). Blocks proliferation of Ba/F3 cells expressing BCR-ABL1 (T315I). Orally available.
Specifications

Chemical Identifiers

Axitinib
C22H18N4OS
386.47
N-Methyl-[[3[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-benzamide

Specifications

Axitinib
>99%
386.47
50mg
319460-85-0
C22H18N4OS
N-Methyl-[[3[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-benzamide
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