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Axitinib, Tocris Bioscience™

Potent VEGFR-1, -2 and -3 inhibitor

Brand:  RD Systems (Bio-Techne) 4350/50

Code : Z1

Additional Details : Weight : 0.00050kg

Quantity 50mg

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Product Code. 13464604

  • £779.48 / 50mg


Estimated Shipment
08-01-2019
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Description

Description

Potent inhibitor of VEGFR-2, -3, and -1 (IC50 values are 0.2, 0.1-0.3, and 1.2 nM respectively). Exhibits minimal activity against a panel of ∽100 protein kinase. Inhibits angiogenesis and vascular permeability. Also a high affinity BCR-ABL1 (T315I) inhibitor (Ki = 149 pM for autophosphorylated ABL1 (T315I)). Blocks proliferation of Ba/F3 cells expressing BCR-ABL1 (T315I). Orally available.
Specifications

Chemical Identifiers

319460-85-0
386.473
axitinib, inlyta, axitinibum, unii-c9lvq0yuxg, e-n-methyl-2-3-2-pyridin-2-yl vinyl-1h-indazol-6-yl thio benzamide, c9lvq0yuxg, n-methyl-2-3-1e-2-pyridin-2-yl ethenyl-1h-indazol-6-yl sulfanyl benzamide, n-methyl-2-3-e-2-pyridin-2-yl ethenyl-1h-indazol-6-yl sulfanyl benzamide, e-n-methyl-2-3-2-pyridin-2-yl vinyl-1h-indazol-6-ylthio benzamide, dsstox_cid_28975
CHEBI:66910
CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)C=CC4=CC=CC=N4
C22H18N4OS
RITAVMQDGBJQJZ-FMIVXFBMSA-N
6450551
N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide

Specifications

Axitinib
319460-85-0
axitinib, inlyta, axitinibum, unii-c9lvq0yuxg, e-n-methyl-2-3-2-pyridin-2-yl vinyl-1h-indazol-6-yl thio benzamide, c9lvq0yuxg, n-methyl-2-3-1e-2-pyridin-2-yl ethenyl-1h-indazol-6-yl sulfanyl benzamide, n-methyl-2-3-e-2-pyridin-2-yl ethenyl-1h-indazol-6-yl sulfanyl benzamide, e-n-methyl-2-3-2-pyridin-2-yl vinyl-1h-indazol-6-ylthio benzamide, dsstox_cid_28975
CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)C=CC4=CC=CC=N4
386.473
CHEBI:66910
>99%
50mg
C22H18N4OS
RITAVMQDGBJQJZ-FMIVXFBMSA-N
N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide
6450551
386.47
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