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Invitrogen™ Human TEM8 Synthetic Peptide
Synthetic Peptide
Brand: Invitrogen™ PEP0135
Code : NEW
Additional Details : Weight : 0.01000kg
Description
ATR/TEM8 Synthetic Peptide, PEP-0135, from Invitrogen.
The Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8). This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin. Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF). This complex is then endocytosed by the cell; acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis. This peptide corresponds to 13 amino acids near the center of human TEM8.PEP-0135 can be used as a blocking peptide with polyclonal antibody PA5-20016.Specifications
84168 | |
purified | |
Human TEM8 | |
-20°C | |
Liquid | |
Blocking Assay, Control | |
No | |
Peptide | |
RUO - research use only |
Human | |
Q9H6X2 | |
200 μg/mL | |
Synthetic Peptide | |
PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2 | |
ANTXR1 | |
0.02% sodium azide | |
50 μg | |
PBS |