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APP (Amyloid Precursor Protein) Mouse, Clone: 22C11, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9749-82

Code : NEW

Additional Details : Weight : 0.09500kg

 View more versions of this product

Product Code. 15577626

  • £167.38 / 100µg


Estimated Shipment date
from Supplier 21-11-2017
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Disclaimers:

For Research Use Only.


Description

Description

The monoclonal antibody 22C11 recognizes human, mouse, and rat APP (Amyloid Precursor Protein). APP is expressed in high abundance in the central nervous system and has three major isoforms resulting from alternative splicing. APP plays a role in synaptic formation and repair, anterograde neuronal transport, iron export, and hormonal regulation. Secreted APP (sAPP) may have neuroprotective effects against neurotoxic insult, oxidative stress, and excitotoxicity. APP belongs to a family that contains at least two homologs, amyloid precursor-like proteins 1 and 2 (APLP1 and APLP2). Similarities between APP and APLP, especially APLP2, suggest that APLP could share and compensate for the function of APP. Proteolytic cleavage of APP results in the generation of beta amyloid, which is the primary component of senile plaques. Senile plaques are one of the major histopathologic features of Alzheimer’s disease. Abnormal regulation and processing of APP also plays a role in Down’s syndrome, early onset familial Alzheimer’s disease, cerebral hemorrhage, and arthritis.

This 22C11 antibody reacts with pre-A4 and recognizes all three isoforms of APP (immature, sAPP, and mature). This 22C11 antibody is known to cross react with APLP2.
Specifications

Specifications

APP (Amyloid Precursor Protein)
22C11
Unlabeled
Purified
Murine
100μg
Store at 2-8°C.
Monoclonal
Microscopy
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Alzheimer Precursor Protein A4
IgG1
RUO
Primary
Rat