Transferrin Receptor/CD71 Monoclonal Antibody, Clone: H68.4, Invitrogen™

Transferrin Receptor/CD71 Antibody (H68.4), 13-6890, from Invitrogen™. Species Reactivity: Chicken, Hamster, Human, Mouse, Rat; Applications: ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunomicroscopy, Immunoprecipitation, Western Blot

Overview
Brand: Invitrogen

Manufacturer Part Number: 136890

UNSPSC: 12352203

Code: 50

Additional Details:
Additional Details: Weight: 0.50000kg



Product Code. 10516083

Quantity Price
1 £ 696.0 / Each
EU Stock 2
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For Research Use Only. All usage must comply with product instructions.
 

Description and Specification

Specification

Cross Reactivity Chicken
Cross Reactivity Hamster
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Rat
Antigen Transferrin Receptor/CD71
Formulation 500μg of Affinity chromatography antibody in PBS with 0.1% sodium azide; pH 7.4.
Storage Requirements Store at -20°C
Isotype IgG1
Immunogen Recombinant human transferrin receptor.
Primary or Secondary Primary
Clone H68.4
Format Affinity Purified
Gene Accession No. P02786, Q62351, Q90997, Q99376
Conjugate Unlabeled
Host Species Mouse
Monoclonal or Polyclonal Monoclonal
Purification Method Affinity chromatography
Gene ID (Entrez) 22042, 396191, 64678, 7037

CD71 (transferrin receptor) is a type II transmembrane glycoprotein expressed as homodimer in erythroid blood cell line and in activated leukocytes. Upon binding of holotransferrin (complex of transferrin and iron ions), CD71 is internalized by clathrin-mediated endocytosis. Acidification of endosomes by vesicular membrane proton pumps leads to dissociation of iron ions, whereas transferrin (apotransferrin) remains associated with CD71 and recycles to the cell surface, where it is released upon exposure to normal pH. CD71 is also involved in uptake of non-transferrin bound iron.
Host Species: Mouse
Cross Reactivity: Chicken, Hamster, Human, Mouse, Rat
Isotype: IgG1
Clone: H68.4
Immunogen: Recombinant human transferrin receptor.
Formulation: 500μg purified antibody in PBS and 0.1% sodium azide; pH 7.4
Synonyms: CD71, T9, TFR, TFR1, TR, TRFR, p90, transferrin receptor protein 1
Uniprot Accession: P02786, Q62351, Q90997, Q99376
Entrez GeneID: 22042, 396191, 64678, 7037
Gene Symbol: TFRC
This product detects Transferrin Receptor/CD71 in Chicken, Hamster, Human, Mouse and Rat samples. This product has been successfully used in ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunomicroscopy, Immunoprecipitation and Western Blot procedures. The immunogen is Recombinant human transferrin receptor..
References:
Test: Flow, Species: Hm, Reference: Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef. (2011) PLoS ONE, Vol: 6, 5, e20033, Breuer S,Schievink SI,Schulte A,Blankenfeldt W,Fackler OT,Geyer M; Pubmed ID: 21625496

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