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SFTPA1 Mouse anti-Human, Biotin, Clone: 6F10, Invitrogen™
Mouse Monoclonal Antibody
Brand: Invitrogen HYB23804B01
Code : LD
Additional Details : Weight : 0.01000kg
Description
HYB 238-04B-01 detects Surfactant protein A in human samples . HYB 238-04B-01 has been successfully used in ELISA procedures. In Western blotting after SDS-PAGE, HYB 238-04B-01 reacts with reduced forms of SP-A and weaker with non-reduced Forms. In immunohistochemical staining from paraffin embedded tissue samples, HYB 238-04B-01 reacts specifically with human SP-A. Immunoreactivity is seen with alveolar type II cells, nonciliated bronchial cells and a subset of alveolar macrophages. No reactivity in samples from pancreas, intestines, thymus, prostate gland or the peritoneal cavity lining cells. The HYB 238-04B-01 immunogen is native SP-A purified from bronchioaveolar lavage from proteinosis patients. NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL
Surfactant protein A (SP-A) is synthesized and secreted by lung epithelial cells. It belongs to group III of the family of C-type lectins and members of this group has overall structure consisting of multiple globular ′head′ regions linked by triple-helical, collagen-like, strands. This group also includes SP-D and the serum proteins man-binding protein, conglutinin and collectin-43, all of which have been shown to bind to the C1q receptor found on a wide variety of cells. Both SP-D and SP-A have been shown to enhance oxygen radical production by alveolar macrophages. The serum concentration is 45 ng/mL in healthy individuals.Specifications
SFTPA1 | |
Monoclonal | |
1 mg/mL | |
SFTPA1 | |
Pulmonary surfactant-associated protein A, SP-A | |
Mouse | |
Purified | |
RUO | |
653509 | |
4° C, store in dark | |
Liquid |
ELISA | |
6F10 | |
Biotin | |
Q8IWL2 | |
SFTPA1 | |
Native SP-A purified from bronchioaveolar lavage from proteinosis patients. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG1 κ |