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Stat1 Mouse, Unlabeled, Clone: 1/STAT1, BD
Mouse Monoclonal Antibody
£255.00 - £441.00
Specifications
Antigen | Stat1 |
---|---|
Clone | 1/STAT1 |
Concentration | 250μg/mL |
Applications | Western Blot |
Classification | Monoclonal |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15865269
|
BD Biosciences
610115 |
50 μg |
£255.00
1 set |
Estimated Shipment: 02-05-2024 Log in to see stock. |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
15875269
|
BD Biosciences
610116 |
150 μg |
£441.00
1 set |
Estimated Shipment: 02-05-2024 Log in to see stock. |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
Description
Stat (Signal transducer and activators of transcription) proteins are critical mediators of the biologic activity of cytokines, including interleukins, interferons, erythropoietin, and growth factors. Ligand-receptor interaction leads to activation of constitutively associated JAK family kinases and subsequent recruitment/activation of Stat proteins by tyrosine phosphorylation. Active Stat proteins then move to the nucleus to promote transcription of cytokine-inducible genes. Seven Stat proteins have been cloned, each of which is differentially expressed and/or activated in a cytokine-specific and cell type-specific manner. Stat1 and Stat2 are components of the ISGF3 (Interferon-Stimulated Gene Factor 3) complex, which is the primary transcription activator induced by the binding of the interferon to a specific cell-surface receptor. Stat1 has two alternatively spliced isoforms, 91kDa Stat1α and 84kDa Stat1β; Stat1α has 38 additional C-terminal amino acids. In response to the binding of IFNα, IFNγ, EGF, PDGF, or CSF-1 to their respective receptors, the Stat1 subunits become tyrosine-phosphorylated at Y701, and the complex is translocated to the nucleus. This results in the formation of an active complex that includes the DNA-binding p48 subunit. This complex is responsible for modulating the transcription of the interferon-stimulated genes (ISGs). Thus, phosphorylation of Y701 in Stat1 occurs in response to growth factors and cytokines, and is essential for normal transcriptional activity of the ISGF3 complex.
Host Species: Mouse
Clone: 1
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human Stat1 aa. 1-194
Formula Weight [Chemical]: 91/84kDa
Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
Specifications
Stat1 | |
250μg/mL | |
Monoclonal | |
Mouse | |
Cell Biology | |
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
IgG1 | |
Affinity Purified |
1/STAT1 | |
Western Blot | |
Unconjugated | |
RUO | |
Canine, Chicken, Frog, Human, Mouse, Rat | |
Human Stat1 aa. 1-194 | |
Primary | |
Store undiluted at -20°C. |
For Research Use Only.