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Phospho-PKR (Thr451) Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA538149
Code : NEW
Additional Details : Weight : 0.00900kg
Description
PKR is a 68 kDa protein and an IFN-induced serine/threonine protein kinase consisting of two N-terminal RNA-binding regulatory domains and a functional C-terminal serine/threonine protein kinase domain. Activated by dsRNA produced during viral infections, PKR plays a key role in IFN induced-innate antiviral response, virus-induced apoptosis, cell growth & differentiation. Upon activation, PKR gets autophosphorylated and catalyzes the phosphorylation of elF2 alpha subunit, which leads to an inhibition of protein synthesis. PKR induces apoptosis by up-regulating Fas expression and mediates FADD/Caspase-8 death signaling pathway. Upon viral infection, it functions as a dual protein, sequentially activating both cell survival & cell death pathways using kinase independent and dependent strategies. PRKR regulates multiple pathways which include NF-kappaB activation, p53, p38, & PDGF signaling pathway. PKR has been implicated in tumor suppression & maligcy. To evade the antiviral effects of PKR, viruses have evolved multiple mechanisms, such as the inhibition of PKR by the non-structural protein (NS1) of the influenza virus. More recently, PKR has been implicated in several neurodegenerative diseases including Alzheimer, Huntington, and amyotrophic lateral sclerosis.Specifications
Phospho-PKR (Thr451) | |
Polyclonal | |
Unconjugated | |
EIF2AK2 | |
EIF2AK2 , Interferon-induced, double-stranded RNA-activated protein kinase | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
19106, 5610 | |
-20°C | |
Liquid |
Immunohistochemistry (Paraffin) | |
1 mg/mL | |
Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4 | |
P19525, Q03963 | |
EIF2AK2 | |
A synthetic phosphopeptide derived from human PKR around the phosphorylation site of Thr451(K-G-TP-L-R) | |
100 μg | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |