missing translation for 'onlineSavingsMsg'
Learn More

Phospho-PKR (Thr451) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA538149

Code : NEW

Additional Details : Weight : 0.00900kg

Product Code. 15585071

This item is currently unavailable or has been discontinued.
View the product page for possible alternatives.


Description

Description

PKR is a 68 kDa protein and an IFN-induced serine/threonine protein kinase consisting of two N-terminal RNA-binding regulatory domains and a functional C-terminal serine/threonine protein kinase domain. Activated by dsRNA produced during viral infections, PKR plays a key role in IFN induced-innate antiviral response, virus-induced apoptosis, cell growth & differentiation. Upon activation, PKR gets autophosphorylated and catalyzes the phosphorylation of elF2 alpha subunit, which leads to an inhibition of protein synthesis. PKR induces apoptosis by up-regulating Fas expression and mediates FADD/Caspase-8 death signaling pathway. Upon viral infection, it functions as a dual protein, sequentially activating both cell survival & cell death pathways using kinase independent and dependent strategies. PRKR regulates multiple pathways which include NF-kappaB activation, p53, p38, & PDGF signaling pathway. PKR has been implicated in tumor suppression & maligcy. To evade the antiviral effects of PKR, viruses have evolved multiple mechanisms, such as the inhibition of PKR by the non-structural protein (NS1) of the influenza virus. More recently, PKR has been implicated in several neurodegenerative diseases including Alzheimer, Huntington, and amyotrophic lateral sclerosis.
Specifications

Specifications

Phospho-PKR (Thr451)
Polyclonal
Unconjugated
EIF2AK2
EIF2AK2 , Interferon-induced, double-stranded RNA-activated protein kinase
Rabbit
Antigen affinity chromatography
RUO
19106, 5610
-20°C
Liquid
Immunohistochemistry (Paraffin)
1 mg/mL
Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
P19525, Q03963
EIF2AK2
A synthetic phosphopeptide derived from human PKR around the phosphorylation site of Thr451(K-G-TP-L-R)
100 μg
Primary
Human, Mouse
Antibody
IgG
Product Suggestions

Product Suggestions

Videos
SDS
Documents

Documents

Certificates
Special Offers

Special Offers