Phospho-p70 S6 Kinase (Thr229) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Marke:  Invitrogen PA538306

Artikelnummer. 15535231

Beschreibung

The p70 S6 kinase (p70 Ribosomal Protein S6 Kinase, p70S6K) is a 70 kDa member of the ribosomal S6 kinase (RSK) family of serine/threonine kinases. p70 S6 kinase is predomitly localized in the cytoplasm, and is essential in growth factors regulated cell proliferation, pathways involving cell motility, such as metastases, the immune response, and tissue repair. p70 S6 kinase acts downstream of phosphoinositide (PI) 3-kinase, and its main physiological target is the S6 ribosomal protein, which is involved in upregulation of protein synthesis. The kinase activity of p70 S6 kinase leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding p70 S6 kinase and overexpression are seen in some breast cancer cell lines.

Spezifikation

• Antigen: Phospho-p70 S6 Kinase (Thr229)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RPS6KB1
• Gene Alias: Ribosomal protein S6 kinase I, S6K, S6K1, 70 kDa ribosomal protein S6 kinase 1, p70 S6 kinase alpha, p70 S6K, p70-S6K, P70S6K, p70 S6 kinase alpha, Name: RPS6KB1, STK14A, p80 S6K1, p85 S6 kinase, p85 S6K, p85S6K
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6198, 72508, 83840
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P23443, Q8BSK8, P67999
• Gene Symbols: RPS6KB1
• Immunogen: A synthetic phosphopeptide derived from human P70S6K around the phosphorylation site of Thr229 (T-H-TP-F-C)
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG