anti-Phospho-JAK2 pTyr221 Polyclonal, Thermo Scientific™

Phospho-JAK2 pTyr221 Polyclonal Ab PA5-35832 from Thermo Scientific™ specifically detects Phospho-JAK2 pTyr221 in Hu, Ms and Rt samples, and it is validated for WB

Overview
Brand: Invitrogen

Manufacturer Part Number: A14017

PHOSPHO-JAK2 (TYR221) ANTIBODY

UNSPSC: 12352203

Code: 50

Additional Details:
Additional Details: Weight: 0.01250kg



Product Code. 12033539

Quantity Price
1 £ 295.0 / 100µL
Estimated Shipment date
from Supplier 23-12-2016
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For Research Use Only. All usage must comply with product instructions.
 

Description and Specification

Specification

Antigen Phospho-Jak2 pTyr221
Conjugate Unlabeled
Cross Reactivity Human
Cross Reactivity Mouse
Format Purified
Formulation 100μL of purified antibody in 0.01M HEPES with 100μg/ml BSA, 50% glycerol, 0.15M NaCl, no preservative; pH 7.5.
Gene Accession No. O60674, Q62120
Host Species Rabbit
Immunogen Synthetic phosphopeptide corresponding to residues surrounding Tyr221 of human Jak2 protein.
Isotype IgG
Storage Requirements Store at -20°C
Primary or Secondary Primary
Monoclonal or Polyclonal Polyclonal
Gene ID (Entrez) 16452, 3717

Janus Activating Kinase 2 (JAK2) is one of a number of related tyrosine kinases involved in cytoplasmic signal transduction. In response to a varitety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine residues. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. However, active JAK1 may be required for complex responses. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex.
Host Species: Rabbit
Cross Reactivity: Human, Mouse
Isotype: IgG
Immunogen: Synthetic phosphopeptide corresponding to residues surrounding Tyr221 of human Jak2 protein.
Formulation: 100μL purified antibody in 0.01M HEPES with 100�g/ml BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
Synonyms: EC 2.7.10.2, JAK-2, JAK2, Janus kinase 2, kinase Jak2
Uniprot Accession: O60674, Q62120
Entrez GeneID: 16452, 3717
Gene Symbol: JAK2
This product detects Phospho-Jak2 pTyr221 in Human and Mouse samples. This product has been successfully used in Western Blot procedures. The immunogen is Synthetic phosphopeptide corresponding to residues surrounding Tyr221 of human Jak2 protein..

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