Phospho-Jak2 pTyr221 Polyclonal Antibody, Invitrogen™
Phospho-Jak2 pTyr221 Antibody, A14017, from Invitrogen™. Species Reactivity: Human, Mouse; Applications: Western Blot
Brand: Invitrogen A14017
Code : 50
Additional Details : Weight : 0.01250kg
DescriptionJanus Activating Kinase 2 (JAK2) is one of a number of related tyrosine kinases involved in cytoplasmic signal transduction. In response to a varitety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine residues. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. However, active JAK1 may be required for complex responses. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex.
Host Species: Rabbit
Cross Reactivity: Human, Mouse
Immunogen: Synthetic phosphopeptide corresponding to residues surrounding Tyr221 of human Jak2 protein.
Formulation: 100μL purified antibody in 0.01M HEPES with 100μg/ml BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
Synonyms: EC 22.214.171.124, JAK-2, JAK2, Janus kinase 2, kinase Jak2
Uniprot Accession: O60674, Q62120
Entrez GeneID: 16452, 3717
Gene Symbol: JAK2
This product detects Phospho-Jak2 pTyr221 in Human and Mouse samples. This product has been successfully used in Western Blot procedures. The immunogen is Synthetic phosphopeptide corresponding to residues surrounding Tyr221 of human Jak2 protein..
|100μL of purified antibody in 0.01M HEPES with 100μg/ml BSA, 50% glycerol, 0.15M NaCl, no preservative; pH 7.5.|
|Synthetic phosphopeptide corresponding to residues surrounding Tyr221 of human Jak2 protein.|
|Store at -20°C|