Myeloperoxidase Polyclonal Antibody, Invitrogen™
Myeloperoxidase Antibody, PA1-18308, from Invitrogen™. Species Reactivity: Human; Applications: Immunohistochemistry (Paraffin, Frozen), Western Blot.
Brand: Invitrogen PA118308
Code : LD
Additional Details : Weight : 0.01000kg
DescriptionMyeloperoxidase is a hemoprotein that is abundantly expressed in neutrophils and secreted during their activation. Native Myeloperoxidase is represented as a covalently bound tetrameric complex of two glycosylated alpha chains (MW ∽59 - 64 kDa) and two unglycosylated beta chains (MW ∽14 kDa) with total MW ∽150 kDa and theoretical pI 9.2. Traditionally Myeloperoxidase was considered as a main target of anti-neutrophil cytoplasm antibodies (ANCA), the serological markers for certain systemic vasculities e.g. periarteriitis nodosa, microscopic polyarteriitis and pulmonary eosinophilic granulomatosis (Churg-Strauss syndrome). Low to moderate anti-Myeloperoxidase autoantibody levels are also reported in rheumatoid arthritis. Recently it was shown that Myeloperoxidase participates in the initiation and progression of cardiovascular disease. It possesses potent proinflammatory properties and may contribute directly to tissue injury. Now Myeloperoxidase is under consideration as one of the most promising cardiac markers.
Host Species: Rabbit
Cross Reactivity: Human
Immunogen: Myeloperoxidase isolated from human polymorphonuclear leucocytes.
Formulation: 250μg purified antibody (1mg/mL) and no preservative
Uniprot Accession: P05164
Entrez GeneID: 4353
Gene Symbol: MPO
PA1-18308 detects Myeloperoxidase from human samples. PA1-18308 has been successfully used in immunohistochemistry (paraffin and frozen) and Western blot procedures. The PA1-18308 immunogen is Myeloperoxidase isolated from human polymorphonuclear leucocytes. Reconstitute with 250 ul of distilled water.
Test: IHC, Species: Hu, Reference: Analysis of IL-17(+) cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response. (2011 Jun 20) Arthritis Res Ther, Vol: 13, 3, R95, Appel H, Maier R, Wu P, Scheer R, Hempfing A, Kayser R, Thiel A, Radbruch A, Loddenkemper C, Sieper J; Pubmed ID: 21689402
|Avoid Freeze/Thaw Cycles|
|250μg purified antibody (1mg/mL) and no preservative|
|Myeloperoxidase isolated from human polymorphonuclear leucocytes.|