anti-Myeloperoxidase Polyclonal, Thermo Scientific™

Myeloperoxidase Polyclonal Ab PA1-18308 from Thermo Scientific™ specifically detects Myeloperoxidase in Hu samples, and it is validated for IHC (Paraffin, Frozen) and WB

Overview
Brand: Invitrogen

Manufacturer Part Number: PA1-18308

MYELOPEROXIDASE

UNSPSC: 12352203

Code: LD

Additional Details:
Additional Details: Weight: 0.01000kg



Product Code. 11501982

Quantity Price
1 £ 330.0 / 250µg
Estimated Shipment date
from Supplier 05-01-2017
Add to basket


Description and Specification

Specification

Antigen Myeloperoxidase
Applications Frozen)
Applications Immunohistochemistry (Paraffin
Applications Western Blot
Conjugate Unlabeled
Cross Reactivity Human
Format Purified
Formulation 250μg purified antibody (1mg/mL) and no preservative
Gene Accession No. P05164
Gene Alias MPO
Gene Symbols MPO
Host Species Rabbit
Immunogen Myeloperoxidase isolated from human polymorphonuclear leucocytes.
Isotype IgG
Quantity 250μg
Species Reactivity Human
Storage Requirements Avoid Freeze/Thaw Cycles
Primary or Secondary Primary
Monoclonal or Polyclonal Polyclonal
Gene ID (Entrez) 4353

Myeloperoxidase is a hemoprotein that is abundantly expressed in neutrophils and secreted during their activation. Native Myeloperoxidase is represented as a covalently bound tetrameric complex of two glycosylated alpha chains (MW ∽59 - 64 kDa) and two unglycosylated beta chains (MW ∽14 kDa) with total MW ∽150 kDa and theoretical pI 9.2. Traditionally Myeloperoxidase was considered as a main target of anti-neutrophil cytoplasm antibodies (ANCA), the serological markers for certain systemic vasculities e.g. periarteriitis nodosa, microscopic polyarteriitis and pulmonary eosinophilic granulomatosis (Churg-Strauss syndrome). Low to moderate anti-Myeloperoxidase autoantibody levels are also reported in rheumatoid arthritis. Recently it was shown that Myeloperoxidase participates in the initiation and progression of cardiovascular disease. It possesses potent proinflammatory properties and may contribute directly to tissue injury. Now Myeloperoxidase is under consideration as one of the most promising cardiac markers.
Host Species: Rabbit
Cross Reactivity: Human
Isotype: IgG
Immunogen: Myeloperoxidase isolated from human polymorphonuclear leucocytes.
Formulation: 250μg purified antibody (1mg/mL) and no preservative
Synonyms: MPO
Uniprot Accession: P05164
Entrez GeneID: 4353
Gene Symbol: MPO
PA1-18308 detects Myeloperoxidase from human samples. PA1-18308 has been successfully used in immunohistochemistry (paraffin and frozen) and Western blot procedures. The PA1-18308 immunogen is Myeloperoxidase isolated from human polymorphonuclear leucocytes. Reconstitute with 250 ul of distilled water.
References:
Test: IHC, Species: Hu, Reference: Analysis of IL-17(+) cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response. (2011 Jun 20) Arthritis Res Ther, Vol: 13, 3, R95, Appel H, Maier R, Wu P, Scheer R, Hempfing A, Kayser R, Thiel A, Radbruch A, Loddenkemper C, Sieper J; Pubmed ID: 21689402