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MEK2 Mouse, Unlabeled, Clone: 96/MEK2, BD

Mouse Monoclonal Antibody

Brand:  BD Biosciences 610235

Additional Details : Weight : 0.01000kg

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Product Code. 15865349

  • £190.12 / 1 set
Estimated Shipment: 16-12-2021

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Description

Description

MEK (Map/Erk Kinase) 1 and 2 are serine/threonine kinases, also known as MAP kinase kinases (MAP2K1 and 2, MAPKK1 and 2, or MKK1 and 2). They activate the MAP (ctivated Protein) kinases, also known as ERKs (Extracellular signal Regulated Kinases), which are critical kinases in multiple signal transduction pathways that regulate cell growth and differentiation. Activation of MEK 1 and 2 is dependent upon phosphorylation of serines 218 and/or 222 by activated MAP kinase kinase kinases (MAP3Ks), such as the Raf isoforms. Hormones, growth and differentiating factors, or tumor promoters induce Raf activation via activation of Ras proteins. MEK2 is seven amino acids larger and shares 81% identity with MEK1. In cultured cells, MEK2 is activated by serum. In vitro, v-Raf phosphorylates and activatesMEK2. It is thought that all of these activated protein kinases are downstream of the Ras signal transduction pathway and represent an integral part of the Ras mitogenic signal.

The 96/MEK2 monoclonal antibody recognizes MEK2, regardless of phosphorylation status.

Specifications

Specifications

MEK2
96/MEK2
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Mouse
IgG2a
RUO
Store undiluted at -20°C.
Monoclonal
Western Blot
250μg/mL
MAP Kinase Kinase 2; ERK Kinase
Affinity Purified
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
50μg
Cell Biology
Primary
Canine, Chicken, Frog, Human, Murine, Rat
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SDS
Documents
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Special Offers

Special Offers

For Research Use Only.