IRP2 Polyclonal Antibody, Invitrogen™

IRP2 Antibody, PA1-16543, from Invitrogen™. Species Reactivity: Human, Mouse; Applications: Immunocytochemistry, Immunofluorescence, Western Blot.

Overview
Brand: Invitrogen

Manufacturer Part Number: PA1-16543

UNSPSC: 12352203

Code: LD

Additional Details:
Additional Details: Weight: 0.01000kg



Product Code. 11525313

Quantity Price
1 £ 332.0 / 100µL
Estimated Shipment date
from Supplier 27-04-2017
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Description and Specification

Specification

Formulation 100μL purified antibody (1mg/mL) in tris glycine with 0.15M NaCl and 0.05% sodium azide
Gene Symbols IREB2
Gene ID (Entrez) 64602
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Western Blot
Cross Reactivity Human
Cross Reactivity Mouse
Antigen IRP2
Storage Requirements avoiding freeze/thaw cycles.
Immunogen Synthetic peptide corresponding to the N-terminal residues 1-100 of human IRP2 (UniProt P48200).
Isotype IgG
Primary or Secondary Primary
Format Purified
Gene Accession No. Q811J3
Host Species Rabbit
Conjugate Unlabeled
Species Reactivity Mouse
Monoclonal or Polyclonal Polyclonal
Quantity 100μL
Gene Alias Iron-responsive element binding protein 2, IRE-BP 2, Iron regulatory protein 2

Iron regulatory protein 2 (IRP2) is a central post-transcriptional regulator of cellular and systemic iron metabolism. It is a cytosolic RNA-binding protein that binds to stem-loop structures. IRP2 is regulated by iron-mediated proteolysis. Hypoxia is important for normal tissue physiology as well as being a component of several pathophysiological conditions, including heart and cerebrovascular diseases and tumor growth. Because iron and oxygen are closely related, IRP2 also plays a role during hypoxia (low oxygen).
Host Species: Rabbit
Cross Reactivity: Human, Mouse
Isotype: IgG
Immunogen: Synthetic peptide corresponding to the N-terminal residues 1-100 of human IRP2 (UniProt P48200).
Formulation: 100μL purified antibody (1mg/mL) in tris glycine with 0.15M NaCl and 0.05% sodium azide
Synonyms: Iron-responsive element binding protein 2, IRE-BP 2, Iron regulatory protein 2
Uniprot Accession: Q811J3
Entrez GeneID: 64602
Gene Symbol: IREB2
This antibody is predicted to work in human based on 100% sequence homology, however preliminary data shows poor reactivity against human protein. This antibody also has 72% sequence homology with rat. Suggested positive control: 3T3 whole cell lysate.