CXCR4/CD184 Monoclonal Antibody, Clone: 12G5, Invitrogen™
CXCR4/CD184 Antibody (12G5), AHR1462X, from Invitrogen™. Species Reactivity: Human, Non-human primate; Applications: Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Frozen).
Brand: Invitrogen AHR1462X
Code : 50
Additional Details : Weight : 0.02000kg
DescriptionHuman immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CXCR4 (fusin, LESTR or HUMSTR) is a principal coreceptor for T-cell tropic strains of HIV-1 fusion and entry of human white blood cells. CXCR4 is also required for the infection by dual-tropic strains of HIV-1 and mediates CD-4 independent infection by HIV-2. The a-chemokine SDF-1 is the ligand for CXCR4 and prevents infection by T-tropic HIV-1. CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells. CXCR4 messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells. The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV biding sites.
Host Species: Mouse
Cross Reactivity: Human, Non-human primate
Isotype: IgG2a, κ
Immunogen: SIV-infected SupT1 cells injected into Balb/c mice.
Formulation: 500μg purified antibody in PBS and no preservative; pH 7.3
Synonyms: D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM, C-X-C chemokine receptor type 4
Uniprot Accession: P61073
Entrez GeneID: 7852
Gene Symbol: CXCR4
This product detects CXCR4/CD184 in Human and Non-human primate samples. This product has been successfully used in Flow Cytometry, Immunohistochemistry and Immunohistochemistry (Frozen) procedures. The immunogen is SIV-infected SupT1 cells injected into Balb/c mice..
|Store at -20°C|
|500μg of Protein A/G antibody in PBS with no preservative; pH 7.3.|
|SIV-infected SupT1 cells injected into Balb/c mice.|