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CD8 alpha Rat anti-Mouse, PE, Clone: YTS169.4, Invitrogen™
Rat Monoclonal Antibody
Brand: Invitrogen MA182111
Code : LD
Additional Details : Weight : 0.01000kg
Description
Reconstitute with 1 mL of distilled water. After reconstitution, store product undiluted at 4°C in the dark. For FACS analysis, use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL.
CD8 (Cluster of Differentiation 8) is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediate efficient cell-cell interactions within the immune system. The CD8 antigen acts as a co-receptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. CD8 is found on a T cell subset of normal cytotoxic/suppressor cells which make up approximately 20-35 % of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer (NK) cells, subpopulations of peripheral blood null cells, thymocytes and bone marrow cells. The CD8 co-receptor functions as either a homodimer composed of two alpha chains, or as a disulfide-linked heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. The majority of CD8+ T cells express CD8 as a alpha/beta heterodimer. In HIV, the HIV-2 envelope glycoprotein binds CD8 alpha chain (but not the beta chain).Specifications
CD8 alpha | |
Monoclonal | |
PE | |
P01731 | |
Cd8a | |
Proprietary Immunogen. | |
100 Tests | |
Primary | |
Mouse | |
Antibody | |
IgG2b |
Flow Cytometry | |
YTS169.4 | |
Cd8a | |
CD8, Leu-2, MAL, p32, CD8a, CD8b, CD8alpha, CD8beta | |
Rat | |
Protein G | |
RUO | |
12525 | |
4° C, store in dark, DO NOT FREEZE! | |
Lyophilized |